Influence of menopause and Type 2 diabetes on pulmonary oxygen uptake kinetics and peak exercise performance during cycling.

Influence of menopause and type 2 diabetes on pulmonary oxygen uptake kinetics and peak 2 exercise performance during cycling

TITLE 1 Influence of menopause and type 2 diabetes on pulmonary oxygen uptake kinetics and peak 2 exercise performance during cycling 3 AUTHORS 4 Catherine Kiely, Joel Rocha, Eamonn O’Connor, Donal O’Shea, Simon Green, Mikel 5 Egaña 6 AFFILIATIONS & ADDRESSES 7 1. School of Medicine, Department of Physiology, Trinity College Dublin, Dublin 2, 8 Ireland. 9 2. Endocrinology, St Columcille’s and S...

Older type 2 diabetic males do not exhibit abnormal pulmonary oxygen uptake and muscle oxygen utilization dynamics during sub-maximal cycling exercise Running head: Oxygen uptake kinetics in older Type 2 diabetic patients

Nitric oxide synthase inhibition reduces glucose uptake during exercise in individuals with type 2 diabetes more than in control subjects.

Nitric oxide (NO) synthase inhibition reduces leg glucose uptake during cycling without reducing leg blood flow (LBF) in young, healthy individuals. This study sought to determine the role of NO in glucose uptake during exercise in individuals with type 2 diabetes. Nine men with type 2 diabetes and nine control subjects matched for age, sex, peak pulmonary oxygen uptake (VO(2) peak), and weight...

Older type 2 diabetic males do not exhibit abnormal pulmonary oxygen uptake and muscle oxygen utilization dynamics during submaximal cycling exercise.

There are reports of abnormal pulmonary oxygen uptake (Vo(2)) and deoxygenated hemoglobin ([HHb]) kinetics in individuals with Type 2 diabetes (T2D) below 50 yr of age with disease durations of <5 yr. We examined the Vo(2) and muscle [HHb] kinetics in 12 older T2D patients with extended disease durations (age: 65 ± 5 years; disease duration 9.3 ± 3.8 years) and 12 healthy age-matched control pa...

Skeletal muscle deoxygenation after the onset of moderate exercise suggests slowed microvascular blood flow kinetics in type 2 diabetes.

OBJECTIVE People with type 2 diabetes have impaired exercise responses even in the absence of cardiovascular complications. One key factor associated with the exercise intolerance is abnormally slowed oxygen uptake (VO2) kinetics during submaximal exercise. The mechanisms of this delayed adaptation during exercise are unclear but probably relate to impairments in skeletal muscle blood flow. Thi...